اثرات تراتوژنیک ویتامین A بر شکل‌گیری لوله عصبی در جنین موش
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ABSTRACT In this study we have tried to analyse the effect of vit.A ampule(retinol )on formation of neural tube (neurulation)in mouse (balb/c)embryo to determine the critical time of its formation and the optimum teratogenic dose of this substance in the experimental induction of neral tube defects(NTD). After we observed the vaginal plug(v.p=0day),mated animals were divided into two groups ,control and experimental ones. The experimental group was subdivided into three groups as A,B,C.VIT.A ampule was injected intraperitoneally by insulin syring in the doses of 1x15000 IU(in group A at 8 a.m),2x100001.U in group B both at 8 a.m and at 14 p.m),2x15000 IU(in group C both at 8a.m and at 14 p.m)on 7th to 10th days of gestation. The embryos were recovered by caesarin section on the 17th day and prepared for morphological investigations.No NTD were observed in cotrol group and group A of experimental embryos,but NTD were observed in group B and C of experimental embryos. The most NTD were observed in groups B and C on the 8th day of gestation which had 6.9% and 9.7% respectively We conclude that the most critical period for neurulation in mouse embryo is on 8th day of gestation(corresponds to about 22nd day in human embryo). Therefore certain teratogenic agents may interfere with their normal development .Also the optimum teratogenic dose of Vit .A in the experimental induction NTD is 2x10000 I.U,which was given both at 8a.m and 14p.m of the 8th day of gestation. This effect may be related to excessive cell death in regions of physiological cell deth in embryological tissues. Furthermore Vitamin.A could lead to increase in mortality rate,decrease in weight,decrease in cranio-caudal length,and morphological defects.
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Journal title
volume 7 issue 25
pages 52- 61
publication date 1999-03
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